地址:武汉市洪山区光谷大道35号光谷总部国际时代 二期1栋1301
电话:18995651644
传真:18771997407
邮箱:sales@amyjet.com

艾美捷科技代理Gene Tools品牌
Gene Tools是一家生产和销售Morpholino Anti-sense oligos(反义寡核苷酸)的公司,其产品专门用于基因调控的科学研究和药物开发。Gene Tools公司由多位资深科学家组成,为全球客户提供免费的技术咨询和Morpholino 序列设计服务。 Morpholino作为基因调控研究的最佳工具,已被广泛用于:阻断靶mRNA 翻译 (下调基因);诱导RNA选择性剪接 (下调或上调基因);阻断 miRNA;阻断病毒 RNA;阻断 non-coding RNA。
▍Morpholino介绍
Morpholino属于第三代反义寡核苷酸,主要通过阻断蛋白质翻译过程而达到抑制目标基因功能的作用,目前已经广泛用于发育生物学和细胞学实验中,并取得了非常好的实验效果。
Morpholino以吗啉环类似物为基本骨架,这种独特的结构特性使得Morpholino 具有以下几个特点:
● 与其他类型的反义寡核苷酸相比,Morpholino 能更好地抵抗核酸酶的作用;
● Morpholino 与靶序列结合后通过空间位阻效应发挥作用, 不激活RNaseH,不引起目标基因mRNA 的降解 ;
● 针对翻译起始位点区设计的Morpholino 用于抑制蛋白质的翻译,针对 pre-mRNA 剪切位点区设计的Morpholino 可影响mRNA 剪切,得到不 同的转录本,可以方便地用于目标基因结构域的突变研究;
● 与靶序列结合能力强,可以渗入mRNA 的二级结构, 并且特异性好。
配合Morpholino 的使用,Gene Tools公司开发了相应的递送系统,可以安全、高效地将Morpholino 输送至胞内,因此,Morpholino 也可以用于遗传学研究和新药靶标的发现以及验证。此外,Morpholino 可以标上荧光基团、亲和标签以及活性反应基团,以供不同的研究需要。

▍Gene Tools公司产品介绍
● Custom Morpholino:可以根据目标基因序列定制设计并合成Morpholino,用于体外细胞实验或某些直接显微注射的模型(如斑马鱼、非洲爪蟾胚胎)。
● Vivo-Morpholino:适用于活体动物模型(小鼠,大鼠,狗,灵长类等),细胞培养,器官培养等。通过特殊的末端修饰,提高了其穿透细胞膜进入组织细胞的能力,使得在成年动物(主要是小鼠、大鼠)中进行系统性基因功能研究成为可能。
● Prepared Control Oligos:根据特定需求合成细胞穿透肽偶联的 Morpholino。适用于活体动物模型(小鼠,大鼠,狗,灵长类等),细胞培养,器官培养等。
| 产品名称 | Short Description | Oligo sequence | SKU |
| Standard Control Oligo | Negative control oligo | CCTCTTACCTCAGTTACAATTTATA | PCO-StandardControl-100 |
| Vivo-Morpholino Standard Control Oligo | Negative Vivo-Morpholino control oligo | CCTCTTACCTCAGTTACAATTTATA | PCO-VivoStandardControl-100 |
| Random Control Oligo 25-N | 25-base random sequence mixture | NNNNNNNNNNNNNNNNNNNNNNNNN | PCO-RandomControl-25N-100 |
| Zebrafish p53 oligo | Danio rerio apoptosis suppression oligo | GCGCCATTGCTTTGCAAGAATTG | PCO-ZebrafishP53-100 |
| Zebrafish Chordin Positive Control Oligo | Danio rerio Chordin positive control oligo | ATCCACAGCAGCCCCTCCATCATCC | PCO-ZebrafishChordin-100-F |
| Clawed Frog Beta Catenin Positive Control Oligo | Xenopus laevis Beta Catenin antisense oligo | TTTCAACCGTTTCCAAAGAACCAGG | PCO-BetaCatenin-100-F |
| Green Fluorescent Protein Positive Control | Translation blocker for GFP target | ACAGCTCCTCGCCCTTGCTCACCAT | PCO-GFPControl-100 |
| Vivo-Morpholino GFP Positive Control | Translation blocker for GFP target (Vivo-Morpholino) | ACAGCTCCTCGCCCTTGCTCACCAT | PCO-VivoGFPControl-100 |
| Fluoresceinated Vivo-Morpholino Std Control | Negative Vivo-Morpholino control oligo with 5'Fluorescein | CCTCTTACCTCAGTTACAATTTATA | PCO-FluorVivoStandardControl-100-F |
● Endo-Porter:为了解决Morpholino在体外培养细胞中摄取效率低的问题,Gene Tools 开发了 Endo-Porter 这种特殊的转染试剂。它通过温和的内吞体逃逸机制帮助Morpholino进入细胞质。
invivoCrown IV0110替换BioXCell BE0058
invivoCrown IV0115替换BioXCell BE0060
invivoCrown IV0101替换BioXCell BE0101

艾美捷科技特约代理Bio X Cell抗体产品。
Bio X Cell位于美国Lebanon, New Hampshire,专注于为生物医药领域制造从毫克到克级的高品质单克隆抗体。
Bio X Cell specializes in manufacturing high quality, bulk quantity (milligram to gram) monoclonal antibodies for biomedical research. All our products are manufactured in the United States in our Lebanon, New Hampshire facility. At Bio X Cell we strive to provide scientists with ultra-pure antibodies targeting both well-characterized and novel antigens in the large quantities required for in vivo preclinical studies. We aim to facilitate the advancement of scientific discovery and innovation by providing our products at outstanding prices and backing them up with exceptional customer and technical support.
Bio X Cell的主要抗体包括:
(1)按CELL TYPE分为
T Cells
B Cells
NK Cells
Neutrophils
Monocytes & Macrophages
Dendritic Cells
(2)按AREA OF RESEARCH分为
Immunology
Innate Immunity
Cancer Biology
Immune Checkpoint Proteins
Cytokines and Chemokines
Cytokine Receptors
Cell Migration & Adhesion
Apoptosis
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invivoCrown IV0114替换BioXCell BE0213
invivoCrown IV0109替换BioXCell BE0164
invivoCrown IV0103替换BioXCell BE0075-1


艾美捷科技代理Biotium品牌全系列染料产品。
Biotium一直致力于开发和生产用于生物医学研究的荧光指示剂及其他特殊生化产品。其产品被广泛应用于细胞生 物学、蛋白质组学、分子生物学、免疫学、微生物学、诊断学、生物化学、神经科学、血液流动检测及大规模药物筛选等众多领域。产品列表如下:
| 产品名称 | 货号 | 规格 | |
| GelRed® Nucleic Acid Gel Stain 10000X in water, 0.5ml | 41003 | 0.5ml | |
| GelRed® Nucleic Acid Gel Stain 10000X in water, 10ml | 41003-1 | 10ml | |
| GelRed® Nucleic Acid Gel Stain 3X in water, 4L | 41001 | 4L | |
| GelRed® Nucleic Acid Gel Stain 10000X in DMSO, 0.5ml | 41002 | 0.5ml | |
| GelRed® Nucleic Acid Gel Stain 10000X in DMSO, 10ml | 41002-1 | 10ml | |
| GelGreen® Nucleic Acid Gel Stain 10000X in water, 0.5ml | 41005 | 0.5ml | |
| GelGreen® Nucleic Acid Gel Stain 10000X in water, 10ml | 41005-1 | 10ml | |
| GelGreen® Nucleic Acid Gel Stain 10000X in DMSO, 0.5ml | 41004 | 0.5ml | |
| GelRed® Agarose LE, 5g | 41029-5G | 5g | |
| GelRed® Agarose LE, 50g | 41029-50G | 50g | |
| GelGreen® Agarose LE, 5g | 41030-5G | 5g | |
| GelGreen® Agarose LE, 50g | 41030-50G | 50g | |
| 6X GelRed® Prestain Loading Buffer with Orange Tracking Dye | 41010 | 1ml | |
| PAGE GelRed® Nucleic Acid Gel Stain 10000X in water, 0.1ml | 41008-T | 0.1ml | |
| PAGE GelRed® Nucleic Acid Gel Stain 10000X in water, 500uL | 41008-500uL | 500ul | |
| PAGE GelRed® Nucleic Acid Gel Stain 1X in water, 4L | 41014 | 4L | |
| RedDot™2 Far-Red Nuclear Stain, 200X in DMSO, 25 uL | 40061-T | 25ul | |
| RedDot™2 Far-Red Nuclear Stain, 200X in DMSO, 250 uL | 40061 | 250ul | |
| RedDot™2 Far-Red Nuclear Stain, 200X in DMSO, 1 mL | 40061-1 | 1ml | |
| EvaGreen® Dye, 20X in Water, 1mL | 31000-T | 1ml | |
| EvaGreen® Dye, 20X in Water, 5 x 1 mL | 31000 | 5x1ml | |
| AO Succinimidyl Ester | 40074 | 5mg | |
| DMAO, 2 mM in DMSO | 40012 | 1ml | |
| EB Succinimidyl Ester | 40072 | 5mg | |
| Ethidium Homodimer III (EthD-III) | 40050 | 1mg | |
| Ethidium Homodimer III (EthD-III), 1 mM in DMSO | 40051 | 200ul | |
| EvaGreen® Dye, 2000X in DMSO | 31019 | 50ul | |
| MB Acid | 40076 | 5mg | |
| MB Succinimidyl Ester | 40075 | 5mg | |
| Thiazole Green (SYBR® Green I), 10,000X in DMSO, 0.5 mL | 40086-0.5mL | 0.5ml | |
| Thiazole Green (SYBR® Green I), 10,000X in DMSO, 1mL | 40086-1mL | 1ml | |
| Thiazole Orange Homodimer (TOTO®-1), 1 mM in DMSO | 40079 | 200ul | |
| Thiazole Orange, 10 mM in DMSO | 40077 | 1mL | |
| Thiazole Red (TO-PRO®-3), 1 mM in DMSO | 40087 | 1mL | |
| Thiazole Red Homodimer (TOTO®-3), 1 mM in DMSO | 40080 | 200ul | |
| TO Succinimidyl Ester | 40073 | 5mg | |
| DAPI, 10 mg | 40011 | 10mg | |
| DAPI, 10 mg (Dilactate) | 40009 | 10mg | |
| DAPI, 1 mL (10 mg/mL) | 40043 | 1ml | |
| Ethidium Homodimer I (EthD-I), 1 mg | 40010 | 1mg | |
| Ethidium Homodimer I (EthD-I), 0.5 mL (2 mM in DMSO) | 40014 | 0.5ml | |
| GelRed® Prestain Plus 6X DNA Loading Dye | 41011 | 1ml | |
| 7-AAD, 1mg | 40037 | 1mg | |
| 7-AAD, 1 mL (1 mg/mL) | 40084 | 1ml | |
| Acridine Orange, 10 mg/mL in Water (High Purity) (AO) | 40039 | 10ml | |
| Actinomycin D | 40038 | 10mg | |
| DiSC2(5) (High Purity) | 40041 | 50mg | |
| DODC (High Purity) | 40040 | 50mg | |
| Ethidium Bromide, 10 mg/mL in H2O | 40042 | 10ml | |
| Hoechst 33258, 10 mL (10 mg/mL) | 40044 | 10ml | |
| Hoechst 33258, 100mg | 40045 | 100mg | |
| Hoechst 33342, 10 mL (10 mg/mL) | 40046 | 10ml | |
| Hoechst 33342, 100mg | 40047 | 100mg | |
| PMAxx™ Dye, 20 mM in H2O | 40069 | 100ul | |
| Propidium Iodide (PI), 10 mL (1 mg/mL in Water) | 40017 | 10ml | |
| Propidium Iodide (PI), 2 mL (50 ug/mL in Buffer) | 40048 | 2ml | |
| Propidium Iodide (PI), 100 mg | 40016 | 100mg | |
| PMA (Propidium Monoazide), 100uL | 40019 | 100ul | |
| PMA (Propidium Monoazide), 1mg | 40013 | 1mg | |
| Ethidium Monoazide Bromide (EMA) | 40015 | 1mg |
invivoCrown IV0109替换BioXCell BE0164
地址:武汉市洪山区光谷大道35号光谷总部国际时代 二期1栋1301
电话:13212737804
传真:15172431432
邮箱:sales@amyjet.com
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